By Sun Hongmao
This e-book will not be an exhaustive survey masking all elements of rational drug layout. in its place, it will supply severe knowledge via real-world examples. suitable case stories could be offered and analyzed to demonstrate the subsequent: the best way to optimize a lead compound no matter if one has excessive or low degrees of structural details; the way to derive hits from opponents’ energetic compounds or from common ligands of the pursuits; tips to springboard from rivals’ SAR wisdom in lead optimization; how one can layout a ligand to intervene with protein-protein interactions by way of adequately interpreting the PPI interface; tips on how to keep away from IP blockage utilizing facts mining; the right way to build and completely make the most of a knowledge-based molecular descriptor process; how you can construct a competent QSAR version through concentrating on info caliber and correct collection of molecular descriptors and statistical techniques. A sensible advisor to Rational Drug Design makes a speciality of computational drug layout, with in simple terms simple assurance of biology and chemistry concerns, resembling assay layout, objective validation and artificial routes.
- Discusses various tactics appropriate to day-by-day drug layout
- Readers can obtain the fabrics utilized in the ebook, together with buildings, scripts, uncooked info, protocols, and codes, making this e-book appropriate source for brief classes or workshops
- Offers a special perspective on drug discovery learn a result of author’s cross-discipline schooling background
- Explores the author’s wealthy studies in either pharmaceutical and educational settings
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A Practical Guide to Rational Drug Design by Sun Hongmao